For you, if you want to maximize the effect of luteolin
Bio-Luteolin™ can:
Promote cellular function & healthy aging
Offer up to 14x increased bioavailability (shown in clinical study)*
Provide innovative fenugreek fiber coating to improve absorption
*Than regular luteolin, defined as 98% pure powder luteolin
Are you occupied with ageing well? Healthy aging begins with your cells. Luteolin is known to support autophagy (cellular "clean-up") and longevity, but is difficult to absorb. Bio-Luteolin™ is up to 14 times* more bioavailable than standard luteolin supplements. The product is gluten-free, non-GMO, and vegetarian.
Health benefits at a glance:
First of all, what is luteolin? It is a naturally occurring plant-derived flavonoid with well-studied antioxidant properties.
Luteolin is gaining growing attention in scientific research and popularity among healthy ageing enthusiasts for its many potential cellular benefits.
However, like many health-promoting flavonoids, it is difficult to absorb. Bio-Luteolin™ combines luteolin with galactomannan fibers from fenugreek seeds to significantly improve bioavailability and maximize its effects.
Why it works:
The function of the cells is the foundation for ageing well. Luteolin is known for supporting cellular health, such as autophagy (cellular "housekeeping"). But, in most forms, it is poorly absorbed, limiting its potential health benefits. (1,3)
The encapsulated coating of galactomannan fibers in Bio-Luteolin™ protects and helps luteolin pass through the digestive system intact, allowing more of it to circulate in the body. The result is up to 14× higher bioavailability and up to 10x free luteolin than compared to regular forms of luteolin. (3)
The science behind the product:
Study of luteolin absorption
In a study (randomized, double-blind, placebo-controlled), participants received luteolin either in its standard form or with the fenugreek fiber coating used in Bio-Luteolin™. Blood plasma levels of both total and free luteolin were measured and found to be significantly higher with the formulated version than with regular luteolin. (3)
Promising clinical evidence
In another trial (randomized, double-blind, placebo-controlled), Bio-Luteolin™ demonstrated clinical efficacy. These results suggest that better absorption allows luteolin to have stronger, more noticeable effects. (4)
Include in your healthy aeging plan today: Bio-Luteolin™, designed for absorption
How to use:
Please take according to the dosage and use guidelines under the supplement facts, or as recommended by a healthcare practitioner.
FAQ:
What does Bio-Luteolin™ contain?
Each capsule provides 100 mg of the Bio-Luteolin™ Proprietary Blend, including 20 mg of luteolin from Japanese sophora extract and 25 mg of galactomannans derived from fenugreek seed.
How does Bio-Luteolin™ work?
As we age, the body's natural cellular "clean-up" process, known as autophagy, becomes less efficient. Luteolin has been shown to support components in autophagy, such as AMPK and mTOR, to activate this process and allow for healthy cell clean-up and function. Bio-Luteolin™ delivers luteolin in a form that is up to 14× more bioavailable than standard luteolin, helping the body make better use of it.
What makes this supplement more bioavailable?
Many flavonoids, including luteolin, are broken down in the digestive system before the body can fully use them. Bio-Luteolin™ includes galactomannans from fenugreek seed, which form a protective matrix around luteolin. This helps slow its breakdown and elimination, allowing higher absorption.
As a result, the 20 mg of luteolin in Bio-Luteolin™ can provide exposure comparable to up to 280 mg of unformulated luteolin.
Who is Bio-Luteolin™ for?
Bio-Luteolin™ is designed for those who want to promote healthy ageing with a more absorbable and bioavailable form of luteolin.
When is the best time to take Bio-Luteolin™?
Take one capsule daily, at any time of day. It can be taken with or without food, depending on your preference.
Will this supplement interact with medications?
There is no indication that the ingredients in this formula negatively interact with prescription medications. However, we recommend informing your healthcare professional about any supplements you are taking.
Has this product been tested for quality and safety?
All Life Extension's raw materials and finished products undergo rigorous testing to ensure they meet their high-quality standards. This includes testing for heavy metals, microbes, disintegration, potency, and active ingredient content. Products are only approved for production after meeting Life Extension's specifications.
Does this supplement contain allergens?
Bio-Luteolin™ is free from milk, eggs, fish, crustacean shellfish, tree nuts, peanuts, wheat, sesame, and soybeans.
Where is this product produced?
This formula is manufactured in the USA in a facility that complies with GMP standards ("good manufacturing practices").
Is this product vegetarian?
Yes, this product is vegetarian and does not contain any animal-derived ingredients.
Is this product gluten-free?
Yes, this product is gluten-free.
Is this product non-GMO?
Yes, this product and all its ingredients are Life Extension verified non-GMO.
Can children take this product?
This product was designed for adults over the age of 18 and is not intended for children. Always consult with your child's physician before giving them any supplements.
Serving Size: 1 capsule
Servings per Container: 30
| Amount per Day (1 capsule): | %RI* | |
|---|---|---|
| Bio-Luteolin Proprietary Blend providing 20% luteolin (20 mg) [from Japanese sophora extract (flower bud)], 25% galactomannans (25 mg) [from fenugreek (seed)] | 100 mg | ** |
*RI = EU reference intake **No RI available
INGREDIENTS:
Galactomannans from fenugreek seed extract (Trigonella foenum-graecum), luteolin from Japanese sophora extract (Fallopia japonica), bulking agent (microcrystalline cellulose / cellulosegel), capsule: hydroxypropyl methyl cellulose, sunflower lecithins, medium chain triglycerides, anti-caking agents (silicon dioxide [nano], magnesium salts of fatty acids)
non-GMO
DIRECTIONS:
Take one (1) capsule daily.
WARNINGS:
- Keep out of reach of children.
- Do not exceed the recommended daily dose.
- Do not purchase if the outer seal is broken or damaged.
- Consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.
- A food supplement should not be used as a substitute for a varied and balanced diet and a healthy lifestyle.
- Store tightly closed in a cool, dry place.
- FEBS Lett. 1998;438(3):220-4.
- Nutrients. 2013;5(9):3367-87.
- Akay. Data on file. Bio-luteolin pharmacokinetics study. 2025.
- Akay. Data on file. Bio-luteolin efficacy study. 2025.