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For you, if you want to nurture a healthy biological aging

Biological Aging Defense can:
  • Promote healthy biological aging by targeting the main hallmarks of aging

  • Help maintain DNA methylation age, a key aging biomarker

  • Support healthy telomere length, a crucial indicator of biological aging

Biological Aging Defense can help you upgrade your healthy aging strategy with a formula designed to support two essential biomarkers: telomere length and DNA methylation age. The supplement contains a standardized extract of the increasingly popular scarlet beebalm together with a lemon balm extract.

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Product details:
Health benefits at a glance

Chronological age is fixed, but biological age is shaped by lifestyle and nutrient intake. Biological Aging Defense once-daily formula contains a standardized extract of scarlet beebalm (Monarda didyma) and a lemon balm extract (Melissa officinalis) to help maintain telomere length and DNA methylation age, two key biomarkers of how aging affects the body's cells, tissues, and organ systems.

The formula is vegetarian, gluten-free, and non-GMO.

Why it works:

A variety of factors influence the natural aging process, including the gradual buildup of oxidative stress in the body. (1-3) Aging can be viewed in two distinct ways:

  • Chronological age
    Chronological age is simply the number of years you've lived, the age marked by birthdays, experiences, memories, personal milestones, and wisdom accumulated throughout your lifetime

  • Biological age
    Biological age offers a different perspective, a laboratory-based estimate that reflects how your cells and systems are functioning over time. It tells whether your body is aging faster or slower than your chronological age and can support you in lifestyle changes to keep you young at the cellular level. (4,5)

This supplement is designed to support healthy biological aging by targeting two core mechanisms that influence how cells age.

The science behind the product:

Preserving the length of the telomeres

Your telomeres function like protective caps at the ends of your chromosomes. Over time, they naturally shorten, and as they do, cells lose their ability to divide and perform optimally, contributing to normal aging.

In a randomized, double-blind, placebo-controlled study, the individuals taking a standardized scarlet beebalm extract maintained notably longer telomere length compared with placebo by the end of the study. (6)

Supporting healthy DNA methylation

What is DNA methylation? The biological process of DNA methylation plays a powerful role in how your body functions. It helps regulate gene activity, acting as an on/off switch for certain genes through epigenetics, which is the processes that influence gene expression and overall health. Because DNA methylation patterns shift as we age, researchers use this biomarker to estimate biological age and evaluate healthy aging at the cellular level.

In the same clinical study, those taking standardized scarlet beebalm extract showed a lower DNA methylation age compared with the placebo group. (6)

Life quality support

Participants in this study also reported improvements in overall quality of life while taking standardized scarlet beebalm extract. (6)


Time moves forward, but Biological Aging Defense can support healthy biological aging

How to use:

Please take according to the dosage and use guidelines under the supplement facts, or as recommended by a healthcare practitioner.

FAQ

What is in Biological Aging Defense?

Biological Aging Defense features a standardized scarlet beebalm extract along with a lemon balm extract providing at least 4% didymin (4 mg). Scarlet beebalm is rich in active compounds, including didymin, that promote healthy aging and overall well-being. Lemon balm serves as a complementary botanical for additional support.

Who is Biological Aging Defense for?

This supplement is ideal for adults who want to support healthy aging from within. It is especially suited for those seeking to maintain important markers of biological age, including youthful gene expression (epigenetics) and telomere length.

What is biological age?

Biological age indicates how well your cells and body systems are functioning, offering a deeper view than chronological age, the number of years you have lived. Lifestyle, genetics, nutrition, and environmental factors all influence biological age, meaning your body can age faster or slower than your actual chronological age.

Epigenetics is the way your body controls which genes are active and which are not — without changing your DNA.

What is DNA methylation & epigenetics?

DNA methylation is a natural process that helps regulate healthy gene expression (through epigenetics), influencing whole-body health and cellular function. As we age, DNA methylation changes, which can affect how genes are expressed and how efficiently cells operate. Scientists measure these methylation patterns as biomarkers to estimate biological age and assess how the body is aging at the cellular level.

Epigenetics is the whole set of gene-control mechanisms, the overall system your body uses to turn genes "on" or "off" without changing your DNA. It includes several mechanisms that influence how your genes behave. DNA methylation is one of those mechanisms used to measure biological ageng.

What are telomeres?

Telomeres are protective caps at the ends of your chromosomes that help safeguard DNA stability. Longer telomeres are associated with youth and longevity. Telomere length, together with epigenetics, plays a central role in how your cells age and function over time.

When can I expect an effect?

In a clinical study using a scarlet beebalm extract standardized to 4% didymin, participants showed a more youthful biological age and longer telomere length after 12 weeks compared with placebo. Individual responses may vary, but following the study's 12-week duration is a good benchmark for evaluating the product's effectiveness.

When is the best time to take Biological Aging Defense? Should it be taken with food or on an empty stomach?

We suggest taking one capsule daily with food.

Can this supplement interact with my medication?

There is no evidence to suggest that the nutrients in this formula would negatively interact with prescription medications. However, it's always recommended to inform your healthcare provider about any supplements you are taking.

Has this product been tested for quality and safety?

All Life Extension's raw materials and finished products undergo rigorous testing to ensure they meet their high-quality standards. This includes testing for heavy metals, microbes, disintegration, potency, and active ingredient content. Products are only approved for production after meeting Life Extension's specifications.

Does this supplement contain allergens?

Biological Aging Defense is free from milk, eggs, fish, crustacean shellfish, tree nuts, peanuts, wheat, sesame, and soybeans.

Where is this product produced?

This formula is manufactured in the USA in a facility that complies with GMP standards ("good manufacturing practices").

Is this formulation vegetarian?

Yes, this product is vegetarian and does not contain any animal-derived ingredients.

Is this product gluten-free?

Yes, this product is gluten-free.

Is this product non-GMO?

Yes, this product and all its ingredients are Life Extension verified non-GMO.

Can children take this product?

This product was designed for adults over the age of 18 and is not intended for children. Always consult with your child's physician before giving them any supplements.

Serving Size: 1 capsule
Servings per Container: 30

Amount per Day (1 capsule): %RI*
Scarlet beebalm extract (aerial parts), lemon balm extract (aerial parts) [std. to ≥ 4% didymin] 100 mg **

*RI = EU reference intake **No RI available

INGREDIENTS:

Scarlet beebalm extract (aerial parts) (Monarda didyma), lemon balm extract (aerial parts) (Melissa officinalis), bulking agent (microcrystalline cellulose/cellulosegel), hydroxypropyl methyl cellulose (capsule), γ-cyclodextrin, food-starch modified, anti-caking agents (magnesium salts of fatty acids, silicon dioxide [nano])

non-GMO

DIRECTIONS:

Take one (1) capsule daily with food.

WARNINGS:
  • Keep out of reach of children.
  • Do not exceed recommended daily dose.
  • Do not purchase if outer seal is broken or damaged.
  • Consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.
  • A food supplement should not be used as a substitute for a varied and balanced diet and a healthy lifestyle.
  • Store tightly closed in a cool, dry place.

  1. Cell. 2014;159(4):709-13.
  2. Cell. 2023;186(2):243-278.
  3. Aging Cell. 2020;19(2):e13080.
  4. Proc Natl Acad Sci U S A. 2015;112(30):E4104-10.
  5. Nat Aging. 2021;1(3):295-308.
  6. Geroscience. 2025;47(3):4253-4290.

Original source/product from Life Extension®