Health Benefits at a Glance:
We know that recycling is good for the environment. But as it turns out, it’s also good for our cells: autophagy is a natural process by which cells clean up intra-cellular debris and other metabolic waste. Tiny cellular organelles called lysosomes breakdown and repurpose this spent material. So why does cellular autophagy matter? Because it helps our bodies conserve energy and function properly, which is essential to living a long, healthy life.
Why it Works:
Piperlongumine is a biologically active alkaloid found in pepper plants. In pre-clinical studies, piperlongumine was shown to activate autophagy as indicated by increased cellular markers called LC3-autophagosomes, structures involved in initiation of autophagy within a cell.3,4
Piperlongumine activates Beclin-1, a gene that triggers formation of these autophagosome structures.5
Luteolin is a flavonoid present in fruits, vegetables and nutritious herbs. We get trace amounts of luteolin in our diets, but not nearly enough to encourage healthy cellular renewal. GEROPROTECT® Autophagy Renew contains 165 mg of luteolin per serving. In pre-clinical studies, luteolin promoted autophagy, leading to a variety of health benefits, particularly in the brain.1
Luteolin supports the cellular pathways that encourage autophagy, such as AMPK signaling.2 Luteolin also promotes the generation of new lysosomes, the “recycling plants” inside your cells that break down waste.2 Plus, luteolin inhibits the processes that discourage autophagy, such as mTOR signaling—a central regulator of cellular metabolism and proliferation.2
Beclin-1 dependent autophagy helps protect delicate mitochondria and helped inhibit inflammation to support cardiovascular health in an animal study.5 Our formula contains 10 mg of piperlongumine.
The Science Behind the Product:
While cellular housekeeping orchestrated by autophagy is a different process than the ones that govern the removal of senescent cells, they are complementary. Therefore, GEROPROTECT® Autophagy Renew can be taken alone, or in conjunction with our Senolytic Activator formula.
How to Use:
- Take one (1) capsule daily, or as recommended by a healthcare practitioner.
Serving Size: 1 capsule
Servings per Container: 30
|Amount per Day (1 capsule):||%RI*|
|Luteolin [from Japanese sophora (flower buds)]||165 mg||**|
|Piperlongumine [from long pepper (root)]||10 mg||**|
*RI = EU Reference Intake ** No RI Available
Ingredients: Japanese sophora (Sophora japonica) flower bud concentrate with luteolin, long pepper (Piper longum L.) root extract with piperlongumine, maltodextrin, capsule (hydroxypropylmethylcellulose), anti-caking agents (fatty acids, silicon dioxide [nano]).
Take (1) capsule daily.
Keep out of reach of children.
Do not exceed recommended daily dose.
Do not purchase if outer seal is broken or damaged.
When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.
A food supplement should not be used as a substitute for a varied and balanced diet and a healthy lifestyle. Store tightly closed in a cool, dry place.
Product reviews are provided for informational purposes only and reflect solely the views and opinions expressed by the contributors and not those of Life Extension. We do not verify or endorse any claims made in these reviews.