TMG non-GMO Blood Pressure Gluten-free Inflammation Glycine Heart

TMG Powder

Can promote healthy homocysteine levels

Item #00349 1 Powder In Stock
TMG non-GMO Blood Pressure Gluten-free Inflammation Glycine Heart

TMG Powder

Can promote healthy homocysteine levels

Item #00349 1 Powder In Stock

For you, if you are interested in supporting cardiovascular health

The innovative formula of TMG Powder can:
  • Encourage healthy homocysteine levels
  • Help inhibit inflammatory factors to promote cardiovascular health
  • Support already-healthy blood pressure levels
  • Promote whole-body health
  • Support healthy mitochondrial function

Trimethylglycine (TMG) has been known as a heart-healthy amino acid compound since the 1950s. That’s more than 50 years of scientific research to rely upon.

If you want capsules instead of powder, you can find it here.

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Product details "TMG Powder"
Health benefits at a glance:

First of all; what is TMG? Trimethylglycine (TMG), also known as glycine betaine, refers to three methyl groups attached to each molecule of glycine. 

When a TMG methyl group is donated to a molecule of homocysteine, it becomes a beneficial amino acid, methionine.

Wheat bran is the main dietary source of TMG, with smaller amounts available in other cereal grains. (1) TMG can also be made in the body from choline, an essential nutrient found in eggs, soybeans, and many other foods. (2,3)

While working to promote healthy levels of homocysteine, alone or in conjunction with other nutrients, TMG has been attested as an important nutrient for cardiovascular health.

Why it works:

TMG has been linked to heart health by supporting already-healthy homocysteine levels to promote healthy cardiovascular function. (7,9)

By having a positive impact on your homocysteine levels, TMG can help you stay healthy by supporting multiple systems throughout your body.

TMG has also been associated with healthy blood pressure and mitochondrial function. (2,10-12) Moreover, it has also been found to promote healthy liver function. (13)

The science behind the product:

In the 1950s, TMG was discovered to be beneficial to the heart and it seems to function in a similar way as some of the B vitamins (B6, B12, and folate). And like B vitamins, TMG is a methyl donor, providing extra methyl groups to hasten the conversion of homocysteine back to methionine. (4-6)

When a TMG methyl group is donated to a molecule of homocysteine, it converts it to the non-toxic amino acid, methionine. (7)

The role of TMG in healthy homocysteine metabolism is even more important when B vitamin levels are low. (8) Some evidence suggests TMG may be more efficient at regulating homocysteine levels than folate. (9) 

Research showing TMG's ability to promote healthy levels of homocysteine already within normal range, alone or in conjunction with other nutrients, confirms its status as an important nutrient for cardiovascular and overall health. (7,9)

Studies show TMG can support a healthy inflammatory response by inhibiting the expression of NFkappaB, TNF-alpha, and other inflammatory proteins, which may partially explain its positive impacts. (14)

Because intestinal microbes can make various by-products from TMG, the health of the gut microbiome influences the effects of TMG in the body. (15,16)

If you want TMG capsules instead of powder, you can find it here.

How to use:

Please take according to the dosage and use guidelines under supplement facts, or as recommended by a healthcare practitioner.

Health topics:
Supplement Facts

50 g
Serving size: 1 rounded scoop (approx. 525 mg)
 Amount per serving
% RI
Trimethylglycine (TMG) (as betaine anhydrous)
500 mg
RI = EU Reference Intake, * no RI available.

Trimethylglycine (TMG) (as betaine anhydrous).
Dosage and use
Take one (1) rounded scoop one to two times per day with or without food, or as directed by a healthcare practitioner.
TMG should be taken with co-factors vitamins B6, B12, and folic acid.
If muscle tension or headaches occur, reduce dose or discontinue product, and inform your physician if they do not subside.
Do not purchase if outer seal is broken or damaged.
If you are undergoing treatment for a medical condition or if you are pregnant or lactating, please consult with your medical practitioner first.
A food supplement should not be used as a substitute for a varied and balanced diet and a healthy lifestyle. Store tightly closed in a cool and dry place.

  1. Foods. 2018;7(4)
  2. ARYA Atheroscler. 2011;7(2):78-86.
  3. Am J Clin Nutr. 2008;88(6):1663-1669.
  4. Ann West Med Surg. 1951;5(10):825-829.
  5. Ann West Med Surg. 1951;5(10):830-855.
  6. Ann West Med Surg. 1951;5(10):863-875.
  7. J Inherit Metab Dis. 2011;34(1):3-15.
  8. Am J Clin Nutr. 2010;91(5):1303-10.
  9. Curr Opin Clin Nutr Metab Care. 2013;16(1):102-108.
  10. J Clin Hypertens (Greenwich). 2018;20(2):388-393.
  11. Biochem Biophys Res Commun. 2015;456(2):621-625.
  12. PLoS One. 2014;9(12):e114969.
  13. Vet Res Forum. 2018;9(2):129-135.
  14. Molecules. 2018;23(6)
  15. Eur Heart J. 2014;35(14):904-910.
  16. Microbiome. 2019;7(1):103.

Original source/product from Life Extension®